Structure-binding relationships of gamma-aminobutyric acid (GABA) and its relatives with GABA and benzodiazepine receptors
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منابع مشابه
P146: Gamma Aminobutyric Acid (GABA) and its Alterations in Stress
Gamma aminobutyrate (GABA) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. Mechanisms by which GABA may facilitate these responses to stress are metabolic and/or mechanical disruptions. Environmental stresses increase GABA accumulation through cytosolic acidification, induce an acidic pH-dependent activation of glutamate...
متن کاملA Review on Gamma-aminobutyric Acid (gaba) and Its Receptors
The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), activates a variety of receptors in all areas of the central nervous system (CNS). GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre and postsynaptic neuronal processes. There are three classes of GABA receptors. GABAA and GABAC receptors are ionotropic in n...
متن کاملp146: gamma aminobutyric acid (gaba) and its alterations in stress
gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...
متن کاملGamma-Aminobutyric Acid (GABA) Monograpy
Introduction Gamma-aminobutyric acid (GABA) is a major neuro transmitter widely distributed throughout the central nervous system (CNS). Because too much excitation can lead to irritability, restlessness, insomnia, seizures, and movement disorders, it must be balanced with inhibition. GABA – the most important inhibitory neurotransmitter in the brain – provides this inhibition, acting like a “b...
متن کاملRegulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C.
Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate induced a continuous decrease in the gamma-aminobutyric acid (GABA)-activated current amplitude from recombinant GABA receptors (formed by rho1 or alphabetagamma subunits) expressed in Xenopus oocytes. This decline was due to internalization of receptors from the plasma membrane as confirmed by a decrease in surface fluores...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1986
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.98.3-4_313